Hepcinat plus contains active ingredients of Sofosbuvir 400mg and Daclatasvir 60mg. Hepcinat plus is a film coated tablet in which it composed of white to yellow colour solid and freely soluble in methanol and water. Hepcinat plus is a oval shape white colour tablet.
Patients with genotype 1 or 4 without cirrhosis by Hepcinat plus is for 12 to 24 weeks prolongation
of therapy before NS3/4A protease inhibitor
Patients with genotype 1 or 4 with compensated cirrhosis by Hepcinat plus for 24 weeks short periods to 12 weeks which provided for previously untreated patients with cirrhosis and low baseline viral load.
Patients with genotype 3 with compensated cirrhosis and experienced treatment by Hepcinat plus + ribavirin for 24 weeks.
Hepcinat plus consist of Sofosbuvir 400mg is an direct-acting antiviral drug which acts
against the hepatitis C virus. It is an inhibitor of the HCV NS5B RNA-dependent RNA polymerase,
which involves for viral poliferation. Sofosbuvir (Hepcinat plus ) is a prodrug of nucleotide
polymerase inhibitor which go through intracellular metabolism to form the active pharmacologically
uridine analog triphosphate (GS-461203),
that may fused into HCV RNA by the NS5B polymerase and process as a chain terminator.
Daclatasvir is also an antiviral regimen which involves inhibitor of nonstructural protein 5A (NS5A), and It acts an multifunctional protein that is an fundamental component of the HCV multiplication complex. Daclatasvir prevents the both viral RNA multiplication and virion accumulation
Daclatasvir is an multiple oral dose and has rapid absorption with peak plasma concentration occurred between 1-2 hours. Where as Sofosbuvir and potent rotating metabolite Gs-331007 has been estimated in healthy adult has peak plasma concentration is -0.5-2 hour post-dose and GS-331007 is 2 to 4 hours post dose.
Plasma protein binding of Daclatasvir is 99% and Sofosbuvir has 61-65% and for the metabolite was minimal human plasma.
Daclatasvir 60mg metabolism based on the substrate of CYP3A with primry CYP isoform and Sofosbuvir is metabolized in the liver which is converted into pharmacologically active nucleoside analog triphosphate GS-461203.
Daclatasvir is eliminated total radioactivity via feces 88% (53% as unchanged) and through urine 6.6% (unchanged drug primarily). Where as Sofosbuvir excreted via urine, feces, and expired air is80%, 14%,2.5% respectively and total recovery is 92%,Half life of Sofosbuvir 400mg and GS-331007 were 0.4 and 27hrs and Daclatasvir 60mg has half life elimination of 12 to 15 hours .
Hepcinat plus composed of two drug combination of sofosbuvir 400mg and Daclatasvir 60mg which is used for the treatment of chronic Hepcinat C virus (HCV) genotype 3 infection in patient.
Hepcinat plus treatment is initiated for the disease of chronic hepatitis C by physician The prescribed dose of Hepcinat plus is Sofosbuvir400mg and Daclatasvir 60mg, which is administrated one tablet once daily taken orally with or without meals.
common side effects:
Very Common Effects:
Head pain, nausea, fatigue
Store below 300C
Container should be its own original bottle. Don’t mix different drugs together.
Keep it in cool, dry place and refrigeration isnecessary, protect from light. Keep reach out of childerns
While travelling in car don’t keep it in glove box, drug can get too hot, cold or wet in box.
Hepcinat plus is contraindicated with hypersensitivity.
Drugs should given with prescription only, without prescription drugs should not be issued.
Hepcinat plus with amiodarone may cause bradycardia
Tell your healthcare providers that you are allergic to daclatasvir , Sofosbuvir or have any other allergies before using the medicine. It may composed of inactive ingredients, that can be cause allergic problems or other reaction. Talk to your pharmacist for more details.
Especially if you have kidney disease, liver disease other than hepatitis C, inform your consultant about past medical history before having daclatasvir / Sofosbuvir.
PREGNANCY: Hepcinat plus should be avoided during pregnancy or in women of child bearing without using contraceptions. When Hepcinat plus combined with ribavirin, contraindication is applicable. Embryocidal effects have been developed in all animal reproduction is exposed to ribavirin, hence special care to be consider and avoid pregnancy in women and the male partners.
LACTATION: Excreted into human milk is unknown therefore the Hepcinat plus is alone or with combination treatment is not recommended during breast feeding.
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